Howard Powell Sant-Roos Olano was born in February 13, 1991. At a height of 2.01 m (6'7") tall, he plays at the small forward and shooting guard positions.
He began playing club basketball at the youth and amateur levels in Italy. Sant-Roos started his pro career in 2011, in the German 3rd Division, with SG Braunschweig, the farm team of the German 1st Division (BBL) team Phantoms Braunschweig.
On June 29, 2015, Sant-Roos signed a two-year deal with the Czech team ČEZ Nymburk. Sant-Roos helped the team to win the Czech Cup in 2017, and the Czech League titles in 2016 and 2017. On June 30, 2017, Sant-Roos joined the NBA's Denver Nuggets' Summer League roster, for the 2017 NBA Summer League.
On July 20, 2017, Sant-Roos signed a one-year deal with the Turkish Super League team Darüşşafaka. In 52 combined league games played (Turkish BSL and EuroCup) during the 2017–18 season, he averaged 7.3 points, 4.6 rebounds and 3.6 assists in the Turkish BSL season, and 8.6 points, 4.2 rebounds and 3.9 assists in the EuroCup season. Sant-Roos won the 2018 EuroCup with Darüşşafaka.
On August 3, 2018, Sant-Roos signed with the Greek Basket League team AEK Athens, for the 2018–19 season. With the Greek club, he won the FIBA Intercontinental Cup in 2019 and gained the reputation of being the best perimeter defender of the team. He averaged 6.6 points, 2.4 assists and 1.2 steals with AEK in the Greek League. On July 14, 2019, Sant-Roos renewed his contract with the Greek club through 2021.
On January 11, 2020, Sant-Roos officially signed with the Russian EuroLeague powerhouse CSKA Moscow through the 2022–23 season, after a buy-out of €500,000 was submitted to and accepted by AEK.