Keifer Jerail Sykes who was born in December 30, 1993 he played college basketball for the University of Wisconsin–Green Bay.
After going undrafted in the 2015 NBA draft, Sykes joined the Cleveland Cavaliers for the 2015 NBA Summer League. On September 28, 2015, he signed with the San Antonio Spurs. Nine days later, he was acquired by the Austin Spurs of the NBA Development League as an affiliate player of San Antonio. In his rookie season with Austin, including the playoffs, Sykes averaged 13.1 points, 3.3 assists, 3.6 rebounds, and 0.84 steals while shooting 45.9% from the field and 77.4% from the free throw line, and also recording a plus/minus of +196.
In the summer of 2016, Sykes joined the Golden State Warriors in the 2016 NBA Summer League. On July 21, 2016, he was selected by Anyang KGC in the second round of the 2016 KBL draft.
In the 2017-18 season, Sykes played for Ankara DSİ S.K. in the Turkish TBL, posting 22.4 points, 3.7 rebounds and 4.8 assists per game.
Sykes signed with Scandone Avellino of the Italian Lega Basket Serie A on August 7, 2018.
He is featured in the 2018 documentary film Chi-Town, produced and directed by Nick Budabin. The film follows Sykes' path from high school to his brush with the NBA.
On August 3, 2019, Sykes signed with the Guangzhou Loong Lions of the Chinese Basketball Association.
On December 27, 2019, Sykes signed with the Olimpia Milano until the end of the season.
On September 13, 2020, he signed with Türk Telekom B.K. of the Basketball Super League.